Vujnic Milorad, Peric Stojan, Popovic Srdjan, Raseta Nela, Ralic Vesna, Dobricic Valerija, Novakovic Ivana, Rakocevic-Stojanovic Vidosava
Faculty of Medicine, University of Banja Luka, Banja Luka, Republic of Srpska, Bosnia and Herzegovina.
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Dr Subotica 6, 11 000, Belgrade, Serbia.
Muscle Nerve. 2015 Aug;52(2):273-7. doi: 10.1002/mus.24540. Epub 2015 Jun 19.
The aim of this study was to assess the frequency and features of metabolic syndrome (MetS) in myotonic dystrophy type 1 (DM1).
We studied 66 DM1 patients (50% men, aged 41.9 ± 10.5 years, disease duration of 19.3 ± 8.6 years). New worldwide consensus criteria for MetS from 2009 were used.
Components of MetS were present at the following frequencies: hypertriglyceridemia 67%; low HDL cholesterol 35%; hypertension 18%; central obesity 14%; and hyperglycemia 9%. MetS was present in 11 (17%) patients. The presence of MetS was not associated with patients' gender, age, disease severity, disease duration, or CTG repeat length (P > 0.05). Patients with MetS had significantly lower total SF-36 scores as a measure of quality of life in comparison to patients without MetS (P < 0.05).
Although certain components of MetS were very frequent in patients with DM1, only 17% met the criteria for MetS.
本研究旨在评估1型强直性肌营养不良（DM1）患者代谢综合征（MetS）的发生率及特征。
我们研究了66例DM1患者（50%为男性，年龄41.9±10.5岁，病程19.3±8.6年）。采用2009年新的全球MetS共识标准。
MetS各组分的发生率如下：高甘油三酯血症67%；低高密度脂蛋白胆固醇35%；高血压18%；中心性肥胖14%；高血糖9%。11例（17%）患者存在MetS。MetS的存在与患者的性别、年龄、疾病严重程度、病程或CTG重复长度无关（P>0.05）。与无MetS的患者相比，有MetS的患者作为生活质量指标的SF-36总分显著更低（P<0.05）。
虽然MetS的某些组分在DM1患者中非常常见，但只有17%的患者符合MetS标准。
