Gajewska E, Sobieska M, Łojko D, Wieczorowska-Tobis K, Suwalska A
Department of Rheumatology and Rehabilitation, Poznań University of Medical Sciences, Poland.
Eur Rev Med Pharmacol Sci. 2014;18(21):3246-50.
In European countries more than 50% of the population are overweight, 30% with obesity. In Poland overweight was present in 41% of men and 28.7% of women (obesity 15.7% and 19.9%). It was examined whether obesity affects serum levels of brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6), which may lead to the consequences of obesity, such as type 2 diabetes, hypertension, and finally the metabolic syndrome. We aimed to examine whether obesity affects the serum levels of BDNF and IL-6.
The study involved 144 people aged 45 to 86 years, 80 subjects with diagnosed obesity and 64 with normal body weight, ≤ 65 years old (n = 45) and > 65 years old (n = 99). All patients underwent tests of glucose, total cholesterol, HDL, LDL, triglycerides levels, using routine laboratory methods. A test of the concentration of IL-6 and BDNF was carried out. The declared level of physical activity (gymnastics, cycling or walking) was considered.
It was shown that in women ≤ 65 years old, obesity was associated with higher levels of interleukin-6. When the test group, divided into the above categories, was analyzed for the diagnosis of hypertension, heart failure or diabetes mellitus, no statistically significant differences in the investigated parameters were detected. The concentration of brain-derived neurotrophic factor did not differ in the investigated subjects, regardless of sex, age, obesity, or the declared physical activity.
The concentration of interleukin-6 in younger people, including those with normal body weight, correlated with total cholesterol and triglyceride levels, and it was significantly higher in obese women compared to those with normal body weight.
在欧洲国家，超过50%的人口超重，30%患有肥胖症。在波兰，41%的男性和28.7%的女性超重（肥胖症分别为15.7%和19.9%）。研究了肥胖症是否会影响血清脑源性神经营养因子（BDNF）和白细胞介素-6（IL-6）水平，而这可能会导致肥胖症的后果，如2型糖尿病、高血压，最终引发代谢综合征。我们旨在研究肥胖症是否会影响BDNF和IL-6的血清水平。
该研究纳入了144名年龄在45至86岁之间的人，其中80名被诊断为肥胖症，64名体重正常，年龄≤65岁（n = 45）以及>65岁（n = 99）。所有患者均采用常规实验室方法进行血糖、总胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯水平检测。进行了IL-6和BDNF浓度检测。考虑了申报的身体活动水平（体操、骑自行车或步行）。
结果显示，在≤65岁的女性中，肥胖症与白细胞介素-6水平较高有关。当对上述分类的试验组进行高血压、心力衰竭或糖尿病诊断分析时，未检测到所研究参数的统计学显著差异。无论性别、年龄、肥胖与否或申报的身体活动水平如何，所研究对象的脑源性神经营养因子浓度均无差异。
包括体重正常者在内的年轻人的白细胞介素-6浓度与总胆固醇和甘油三酯水平相关，肥胖女性的白细胞介素-6浓度显著高于体重正常的女性。
