Tarsitano Achille, Tardio Maria Lucia, Marchetti Claudio
Researcher, Department of Biomedical and Neuromotorial Science, University of Bologna, Maxillofacial Surgery Unit, Policlinico S. Orsola-Malpighi Hospital, Bologna, Italy.
Medical Doctor, Section of Pathology, S. Orsola-Malpighi Hospital, Bologna, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Feb;119(2):221-8. doi: 10.1016/j.oooo.2014.10.004. Epub 2014 Oct 15.
Perineural invasion (PNI) is frequent in oral squamous cell carcinoma (OSCC) and could play an important role in treatment decisions.
This retrospective study used multivariate analysis to evaluate the impact of PNI on locoregional recurrence, neck metastases, and survival in 236 consecutive patients with oral cancer.
There were significant differences in the local (P = .007) and regional (P = .041) failure rates in the PNI-positive group compared with the PNI-negative group. Univariate analysis demonstrated that PNI-positive patients had significantly worse locoregional control (P = .011), disease-specific survival (P = .023), and overall survival (P = .046) compared with PNI-negative patients.
PNI was an independent predictor of local and regional failure in a well-defined, homogeneous population with OSCC.
神经周围侵犯（PNI）在口腔鳞状细胞癌（OSCC）中很常见，并且可能在治疗决策中发挥重要作用。
这项回顾性研究采用多变量分析来评估PNI对236例连续口腔癌患者的局部区域复发、颈部转移和生存的影响。
与PNI阴性组相比，PNI阳性组的局部（P = .007）和区域（P = .041）失败率存在显著差异。单变量分析表明，与PNI阴性患者相比，PNI阳性患者的局部区域控制（P = .011）、疾病特异性生存（P = .023）和总生存（P = .046）明显更差。
在明确界定的、同质的OSCC人群中，PNI是局部和区域失败的独立预测因素。
