Southern Timothy R, VanSchooneveld Trevor C, Bannister Dianna L, Brown TeAnne L, Crismon Amy S, Buss Sarah N, Iwen Peter C, Fey Paul D
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA; Nebraska Public Health Laboratory, Omaha, NE, USA.
Division of Infectious Disease, Department of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Diagn Microbiol Infect Dis. 2015 Feb;81(2):96-101. doi: 10.1016/j.diagmicrobio.2014.11.004. Epub 2014 Nov 15.
The FilmArray® Blood Culture Identification (BCID) panel was recently implemented at a midwestern academic tertiary care hospital to provide rapid identification (ID) of common pathogens from positive blood cultures. This study evaluated the clinical performance of the BCID panel compared to culture-based ID methods. One hundred thirty-eight monomicrobial and 8 polymicrobial blood cultures were evaluated during the 30-day study resulting in the ID of 152 total organisms by culture with 115 organisms correctly identified using the BCID panel. The BCID panel had sensitivities of 80.4% (115/152) for all organisms identified during the study and 94.6% (115/122) when considering only on-panel organisms. BCID panel specificity was 100%. Implementation of the BCID panel was coupled with the development of empiric therapy recommendations for bloodstream infections by the antimicrobial stewardship team. Based on this study, the FilmArray® BCID panel is a rapid and reliable test for the detection of common bloodstream pathogens, and therapeutic decisions can be based upon panel results.
FilmArray®血培养鉴定（BCID）检测板最近在一家中西部学术性三级护理医院投入使用，用于从阳性血培养物中快速鉴定常见病原体。本研究评估了BCID检测板与基于培养的鉴定方法相比的临床性能。在为期30天的研究中，对138份单微生物血培养物和8份多微生物血培养物进行了评估，通过培养共鉴定出152种微生物，其中115种微生物使用BCID检测板正确鉴定。BCID检测板对研究期间鉴定出的所有微生物的敏感性为80.4%（115/152），仅考虑检测板上的微生物时敏感性为94.6%（115/122）。BCID检测板的特异性为100%。抗菌药物管理团队在实施BCID检测板的同时，还制定了针对血流感染的经验性治疗建议。基于本研究，FilmArray® BCID检测板是一种快速、可靠的检测常见血流病原体的方法，治疗决策可基于检测板结果。
