宿主-病原体相互作用中的外泌体及其他细胞外囊泡
Exosomes and other extracellular vesicles in host-pathogen interactions.
作者信息
Schorey Jeffrey S, Cheng Yong, Singh Prachi P, Smith Victoria L
机构信息
Department of Biological Sciences, Eck Institute for Global Health University of Notre Dame, Notre Dame, IN, USA
Department of Biological Sciences, Eck Institute for Global Health University of Notre Dame, Notre Dame, IN, USA.
出版信息
EMBO Rep. 2015 Jan;16(1):24-43. doi: 10.15252/embr.201439363. Epub 2014 Dec 8.
Abstract
An effective immune response requires the engagement of host receptors by pathogen-derived molecules and the stimulation of an appropriate cellular response. Therefore, a crucial factor in our ability to control an infection is the accessibility of our immune cells to the foreign material. Exosomes-which are extracellular vesicles that function in intercellular communication-may play a key role in the dissemination of pathogen- as well as host-derived molecules during infection. In this review, we highlight the composition and function of exosomes and other extracellular vesicles produced during viral, parasitic, fungal and bacterial infections and describe how these vesicles could function to either promote or inhibit host immunity.
摘要
有效的免疫反应需要病原体衍生分子与宿主受体结合，并刺激适当的细胞反应。因此，我们控制感染能力的一个关键因素是免疫细胞接触外来物质的能力。外泌体是在细胞间通讯中起作用的细胞外囊泡，可能在感染期间病原体和宿主衍生分子的传播中发挥关键作用。在这篇综述中，我们重点介绍了病毒、寄生虫、真菌和细菌感染期间产生的外泌体和其他细胞外囊泡的组成和功能，并描述了这些囊泡如何发挥作用来促进或抑制宿主免疫。
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