Celso Constantino Leandra, Tasca Carla Inês, Boeck Carina Rodrigues
Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina-UFSC, Campus Trindade, 88040-900, Florianópolis, SC, Brazil.
Laboratório de Biologia Celular e Molecular, Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Programa de Pós-graduação Ciências da Saúde, Universidade do Extremo Sul Catarinense-UNESC, Criciúma, 88806-000, SC, Brazil.
Aging Dis. 2014 Feb 12;5(6):430-41. doi: 10.14336/AD.2014.0500430. eCollection 2014 Dec.
Brain tolerance or resistance can be achieved by interventions before and after injury through potential toxic agents used in low stimulus or dose. For brain diseases, the neuroprotection paradigm desires an attenuation of the resulting motor, cognitive, emotional, or memory deficits following the insult. Preconditioning is a well-established experimental and clinical translational strategy with great beneficial effects, but limited applications. NMDA receptors have been reported as protagonists in the adjacent cellular mechanisms contributing to the development of brain tolerance. Postconditioning has recently emerged as a new neuroprotective strategy, which has shown interesting results when applied immediately, i.e. several hours to days, after a stroke event. Investigations using chemical postconditioning are still incipient, but nevertheless represent an interesting and promising clinical strategy. In the present review pre- and postconditioning are discussed as neuroprotective paradigms and the focus of our attention lies on the participation of NMDA receptors proteins in the processes related to neuroprotection.
通过在损伤前后使用低刺激或低剂量的潜在毒性剂进行干预，可以实现脑耐受性或抗性。对于脑部疾病，神经保护范式期望减轻损伤后产生的运动、认知、情感或记忆缺陷。预处理是一种成熟的实验和临床转化策略，具有很大的有益效果，但应用有限。据报道，NMDA受体在促进脑耐受性发展的相邻细胞机制中起主要作用。后处理最近作为一种新的神经保护策略出现，在中风事件后立即应用，即几小时至几天后应用时，已显示出有趣的结果。使用化学后处理的研究仍处于初期阶段，但仍然是一种有趣且有前景的临床策略。在本综述中，预处理和后处理作为神经保护范式进行了讨论，我们关注的焦点在于NMDA受体蛋白在与神经保护相关的过程中的参与情况。
