University of Athens, Medical School, Mikras Asias 75 st., 115 27 Athens, Greece.
Eur J Pharmacol. 2013 Nov 15;720(1-3):401-8. doi: 10.1016/j.ejphar.2013.10.001. Epub 2013 Oct 8.
Opioids and their receptor agonists have been widely used because of their beneficial effects on pain management and control. Over the past decade, there has been an increasing interest on the experimental use of opioid agonists in the laboratory setting of ischemia and reperfusion; existing data suggest that there is a potential association between opioid agonism and the reduction of infarct size in several animal models of regional ischemia similar to that following ischemic preconditioning. Most of these studies seem to attribute these beneficial and cardioprotective effects to the stimulation of a specific opioid receptor type, the delta (δ) opioid receptor. This review focuses on the role of the delta opioid receptor agonism in several models of ischemia and reperfusion, as well as on hemorrhagic shock models, on the potential mechanisms of action following delta opioid receptor activation and on the time window for opioid administration in various animal studies.
阿片类药物及其受体激动剂因其在疼痛管理和控制方面的有益作用而被广泛应用。在过去的十年中，人们对阿片类激动剂在缺血再灌注的实验室环境中的实验应用越来越感兴趣；现有数据表明，阿片类激动剂与几种类似缺血预处理后局部缺血动物模型的梗死面积减少之间存在潜在关联。这些研究大多似乎将这些有益的和心脏保护作用归因于对特定阿片受体类型，即 δ 阿片受体的刺激。本综述重点介绍了 δ 阿片受体激动剂在几种缺血再灌注模型以及出血性休克模型中的作用，以及 δ 阿片受体激活后的潜在作用机制，以及各种动物研究中阿片类药物给药的时间窗。
