循环肿瘤细胞和上皮、间充质及干性标志物：细胞亚群的特征。
Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations.
机构信息
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Piero Maroncelli 40, 47014 Meldola, FC, Italy.
出版信息
Ann Transl Med. 2014 Nov;2(11):109. doi: 10.3978/j.issn.2305-5839.2014.10.04.
Abstract
Until now detection and numeration of circulating tumor cells (CTCs) were essentially used as a prognostic factor in cancer progression. To extend the role of these kinds of analysis, it seems necessary to improve analytical methods related to isolation and characterization of CTCs. Discrepancies between published results corroborates this requirement. In this review we suggest a combination of markers able to reach the goal. Moreover to improve the clinical utility of CTC analysis, particularly in the therapeutic follow up of the disease, epithelial mesenchymal transition (EMT) level of a global CTC population should be studied.
摘要
到目前为止，循环肿瘤细胞（CTC）的检测和计数主要被用作癌症进展的预后因素。为了扩展这些分析的作用，似乎有必要改进与 CTC 的分离和鉴定相关的分析方法。发表的结果之间的差异证实了这一要求。在这篇综述中，我们建议结合使用能够达到这一目标的标记物。此外，为了提高 CTC 分析的临床实用性，特别是在疾病的治疗随访中，应该研究整个 CTC 群体的上皮间质转化（EMT）水平。
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