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本文引用的文献

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The workflow of single-cell expression profiling using quantitative real-time PCR.使用定量实时PCR进行单细胞表达谱分析的工作流程。
Expert Rev Mol Diagn. 2014 Apr;14(3):323-31. doi: 10.1586/14737159.2014.901154.
2
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.CD44v6 是驱动结肠癌转移的组成性和重编程癌症干细胞的标志物。
Cell Stem Cell. 2014 Mar 6;14(3):342-56. doi: 10.1016/j.stem.2014.01.009.
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Heterogeneous atypical cell populations are present in blood of metastatic breast cancer patients.转移性乳腺癌患者的血液中存在异质性非典型细胞群体。
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Cancer stem cells and tumor metastasis.癌症干细胞与肿瘤转移。
J Cancer Res Ther. 2013 Nov;9 Suppl:S150-2. doi: 10.4103/0973-1482.122510.
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Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts.乳腺癌干细胞在上皮和间充质状态之间转换，反映了它们正常对应物的特征。
Stem Cell Reports. 2013 Dec 27;2(1):78-91. doi: 10.1016/j.stemcr.2013.11.009. eCollection 2014 Jan 14.
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Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells.在乳腺癌细胞上皮-间质转化过程中，ZEB1对MYB的直接抑制作用可抑制细胞增殖并抑制上皮基因表达。
Breast Cancer Res. 2013 Nov 27;15(6):R113. doi: 10.1186/bcr3580.
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Aberrant expression of plastin-3 via copy number gain induces the epithelial-mesenchymal transition in circulating colorectal cancer cells.通过拷贝数增加导致的丝束蛋白-3异常表达可诱导循环中的结直肠癌细胞发生上皮-间质转化。
Ann Surg Oncol. 2014 Oct;21(11):3680-90. doi: 10.1245/s10434-013-3366-y. Epub 2013 Nov 12.
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MicroRNA-based regulation of epithelial-hybrid-mesenchymal fate determination.基于 microRNA 的上皮-混合-间充质命运决定的调控。
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18144-9. doi: 10.1073/pnas.1318192110. Epub 2013 Oct 23.
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Gene of the month: E-cadherin (CDH1).本月基因：E-钙黏蛋白（CDH1）。
J Clin Pathol. 2013 Nov;66(11):928-32. doi: 10.1136/jclinpath-2013-201768. Epub 2013 Aug 12.
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Twist: a molecular target in cancer therapeutics.Twist：癌症治疗中的一个分子靶点。
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循环肿瘤细胞和上皮、间充质及干性标志物：细胞亚群的特征。

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations.

机构信息

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Piero Maroncelli 40, 47014 Meldola, FC, Italy.

出版信息

Ann Transl Med. 2014 Nov;2(11):109. doi: 10.3978/j.issn.2305-5839.2014.10.04.

DOI:10.3978/j.issn.2305-5839.2014.10.04
PMID:25489583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4245517/
Abstract

Until now detection and numeration of circulating tumor cells (CTCs) were essentially used as a prognostic factor in cancer progression. To extend the role of these kinds of analysis, it seems necessary to improve analytical methods related to isolation and characterization of CTCs. Discrepancies between published results corroborates this requirement. In this review we suggest a combination of markers able to reach the goal. Moreover to improve the clinical utility of CTC analysis, particularly in the therapeutic follow up of the disease, epithelial mesenchymal transition (EMT) level of a global CTC population should be studied.

摘要

到目前为止，循环肿瘤细胞（CTC）的检测和计数主要被用作癌症进展的预后因素。为了扩展这些分析的作用，似乎有必要改进与 CTC 的分离和鉴定相关的分析方法。发表的结果之间的差异证实了这一要求。在这篇综述中，我们建议结合使用能够达到这一目标的标记物。此外，为了提高 CTC 分析的临床实用性，特别是在疾病的治疗随访中，应该研究整个 CTC 群体的上皮间质转化（EMT）水平。