直接由[¹¹C]二氧化碳合成¹¹C标记的氯丙嗪。

Synthesis of 11C-labeled chlorpromazine directly from [11C]carbon dioxide.

作者信息

Ram S, Spicer L D

机构信息

Department of Radiology, Duke University Medical Center, Durham, NC 27701.

出版信息

Int J Rad Appl Instrum A. 1989;40(5):413-6. doi: 10.1016/0883-2889(89)90207-4.

DOI:10.1016/0883-2889(89)90207-4

PMID:2548973

Abstract

Radiolabeled chlorpromazine was prepared by carboxylation of the N-trimethylsilyl derivative of norchlorpromazine with [11C]carbon dioxide, followed by in situ lithium aluminum hydride reduction. Radiochemical yields of 22-24% and radiochemical purities in the range of 93-98% were achieved.

摘要

放射性标记的氯丙嗪是通过将去甲氯丙嗪的N-三甲基硅烷基衍生物与[11C]二氧化碳进行羧化反应，然后原位用氢化铝锂还原制备而成。放射化学产率为22 - 24%，放射化学纯度在93 - 98%范围内。