Rapid reductive-carboxylation of secondary amines, one pot synthesis of N'-(4-11C-methyl)imipramine.
作者信息
Ram S, Ehrenkaufer R E, Jewett D M
出版信息
Int J Rad Appl Instrum A. 1986;37(5):391-5. doi: 10.1016/0883-2889(86)90094-8.
PMID:3019941
Abstract
A new rapid high yield synthesis of radiolabeled N'-(4-11C-methyl)imipramine has been developed using a reductive-carboxylation approach, in which 11CO2 is reacted with either N'-trimethylsilyldesimipramine or N'-lithium derivative of desimipramine, followed by lithium aluminum hydride reduction, to give no carrier added or carrier added 11C-labeled imipramine respectively. The final product is characterized by chromatographic and spectroscopic methods.
摘要
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