Chang Pengcheng, Li Yanping, Zhang Zhao, Hwang Daejoon
a Department of Information and Communications Engineering , Sungkyunkwan University , Suwon , Republic of Korea.
b School of Pharmacy, Yunnan University of Traditional Chinese Medicine , Kunming , People's Republic of China , and.
Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Nov;27(6):3897-3898. doi: 10.3109/19401736.2014.987253. Epub 2014 Dec 9.
The sooty mangabey (Cercocebus atys atys) is an Old World monkey belonging to family Cercopithecidae. It has recently been widely used as an important animal model for researches related to human immunodeficiency virus (HIV) and AIDS. In this study, the mitochondrial genome sequence of this species is determined and described for the first time. It is 16,536 bp in length and consists of 13 protein-coding genes, 22 tRNA genes, 2 ribosomal RNA genes and 1 putative control region (CR). The genome organization, nucleotide composition and codon usage are similar to those reported from other monkey mitochondrial genomes. The descending order of the base composition on heavy strand is 32.5% A, 29.5% C, 25.8% T, and 12.2% G, with a relatively lower level of G and a slightly A+T bias of 58.3%. All genes are distributed on the H-strand except for the ND6 subunit gene and seven tRNA genes, which are encoded on the L-strand. This mitochondrial genome data are potentially important for the study of molecular evolution, conservation genetics and disease infection in C. a. atys.
黑冠猕猴（Cercocebus atys atys）是一种属于猕猴科的旧世界猴。它最近被广泛用作与人类免疫缺陷病毒（HIV）和艾滋病相关研究的重要动物模型。在本研究中，首次测定并描述了该物种的线粒体基因组序列。其长度为16,536 bp，由13个蛋白质编码基因、22个tRNA基因、2个核糖体RNA基因和1个假定的控制区（CR）组成。基因组组织、核苷酸组成和密码子使用情况与其他猴线粒体基因组报道的相似。重链上碱基组成的降序排列为32.5%A、29.5%C、25.8%T和12.2%G，G含量相对较低，A+T偏差略为58.3%。除ND6亚基基因和7个tRNA基因在轻链上编码外，所有基因均分布在重链上。这些线粒体基因组数据对于黑冠猕猴的分子进化、保护遗传学和疾病感染研究可能具有重要意义。
