Shakibazad Nader, Honar Naser, Dehghani Seyed Mohsen, Alborzi Abdolvahab
From the Department of Pediatrics, Shiraz University of Medical Sciences, School of Medicine, Nemazee Teaching Hospital, Shiraz, Iran.
Exp Clin Transplant. 2014 Dec;12(6):534-8.
Many children with chronic liver disease require a liver transplant. These patients are prone to various infections, including Epstein-Barr virus infection. This study sought to measure the Epstein-Barr viral load by polymerase chain reaction before a liver transplant.
This cross-sectional study was done at the Shiraz University of Medical Sciences, Shiraz, Iran, in 2011. All patients were aged younger than 18 years with chronic liver disease and were candidates for a liver transplant at the Shiraz Nemazee Hospital Organ Transplant Center. They had been investigated regarding their demographic characteristics, underlying disease, laboratory findings, and Epstein-Barr viral load by real-time TaqMan polymerase chain reaction.
Ninety-eight patients were studied and the mean age was 6.5 ± 5.9 years. Cryptogenic cirrhosis was the most-prevalent reason for liver transplant, and the death rate before a transplant was 15%. Among the study subjects, 6 had measurable Epstein-Barr viral load by polymerase chain reaction before the transplant, and 4 of them had considerably higher Epstein-Barr viral loads (more than 1000 copies/mL).
With respect to the close prevalence of posttransplant lymphoproliferative disease (6%) and the high Epstein-Barr viral load in the patients before a transplant (4%), high pretransplant Epstein-Barr viral load can be considered a risk factor for posttransplant lymphoproliferative disorder.
许多患有慢性肝病的儿童需要进行肝移植。这些患者易发生各种感染，包括爱泼斯坦-巴尔病毒感染。本研究旨在通过聚合酶链反应在肝移植前检测爱泼斯坦-巴尔病毒载量。
这项横断面研究于2011年在伊朗设拉子的设拉子医科大学进行。所有患者年龄均小于18岁，患有慢性肝病，是设拉子内马齐医院器官移植中心肝移植的候选者。通过实时TaqMan聚合酶链反应对他们的人口统计学特征、基础疾病、实验室检查结果和爱泼斯坦-巴尔病毒载量进行了调查。
共研究了98例患者，平均年龄为6.5±5.9岁。隐源性肝硬化是肝移植最常见的原因，移植前死亡率为15%。在研究对象中，6例在移植前通过聚合酶链反应检测到可测量的爱泼斯坦-巴尔病毒载量，其中4例的爱泼斯坦-巴尔病毒载量相当高（超过1000拷贝/mL）。
鉴于移植后淋巴组织增生性疾病的相近患病率（6%）以及移植前患者中较高的爱泼斯坦-巴尔病毒载量（4%），移植前爱泼斯坦-巴尔病毒载量高可被视为移植后淋巴组织增生性疾病的一个危险因素。
