粉饰 Polycomb 抑制。

Sugarcoating Polycomb repression.

机构信息

Department of Biochemistry, Erasmus University Medical Center, P.O. Box 1738, 3000 DR Rotterdam, the Netherlands.

出版信息

Dev Cell. 2014 Dec 8;31(5):521-2. doi: 10.1016/j.devcel.2014.11.027.

DOI:10.1016/j.devcel.2014.11.027

Abstract

The addition of the monosaccharide O-GlcNAc is one of the most mysterious posttranslational modifications. In this issue of Developmental Cell, Gambetta and Müller (2014) show that O-GlcNAcylation of the Drosophila Polycomb group (PcG) protein Polyhomeotic (PH) is essential for homeotic gene silencing. O-GlcNAcylation counteracts nonproductive aggregation of PH, allowing transcriptional repression.

摘要

单糖 O-GlcNAc 的添加是最神秘的翻译后修饰之一。在本期《发育细胞》中， Gambetta 和 Müller（2014）表明，果蝇 Polycomb 组（PcG）蛋白 Polyhomeotic（PH）的 O-GlcNAc 化对于同源基因沉默是必不可少的。O-GlcNAc 化可以阻止 PH 的非生产性聚集，从而允许转录抑制。