Veneti Zoe, Gkouskou Kalliopi K, Eliopoulos Aristides G
Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece.
Embiodiagnostics Ltd., 71202 Heraklion, Greece.
Int J Mol Sci. 2017 Jul 30;18(8):1657. doi: 10.3390/ijms18081657.
Polycomb repressor complexes PRC1 and PRC2 regulate chromatin compaction and gene expression, and are widely recognized for their fundamental contributions to developmental processes. Herein, we summarize the existing evidence and molecular mechanisms linking PRC-mediated epigenetic aberrations to genomic instability and malignancy, with a particular focus on the role of deregulated PRC2 in tumor suppressor gene expression, the DNA damage response, and the fidelity of DNA replication. We also discuss some of the recent advances in the development of pharmacological and dietary interventions affecting PRC2, which point to promising applications for the prevention and management of human malignancies.
多梳抑制复合物PRC1和PRC2调节染色质压缩和基因表达，并因其对发育过程的重要贡献而被广泛认可。在此，我们总结了将PRC介导的表观遗传异常与基因组不稳定和恶性肿瘤联系起来的现有证据和分子机制，特别关注失调的PRC2在肿瘤抑制基因表达、DNA损伤反应和DNA复制保真度中的作用。我们还讨论了影响PRC2的药理学和饮食干预发展方面的一些最新进展，这些进展为人类恶性肿瘤的预防和管理指出了有前景的应用方向。
