Loewen Gregory, Jayawickramarajah Janarthanan, Zhuo Ying, Shan Bin
Providence Regional Cancer Center, 105 W. 8th Avenue, Spokane, WA, 99204, USA.
Department of Chemistry, Tulane University, 2015 Percival Stern Hall, New Orleans, LA, 70118, USA.
J Hematol Oncol. 2014 Dec 10;7:90. doi: 10.1186/s13045-014-0090-4.
Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through recruitment of chromatin modifiers. The expression of HOTAIR is elevated in lung cancer and correlates with metastasis and poor prognosis. Moreover, HOTAIR promotes proliferation, survival, invasion, metastasis, and drug resistance in lung cancer cells. Here we review the molecular mechanisms underlying HOTAIR-mediated aggressive phenotypes of lung cancer. We also discuss HOTAIR's potential in diagnosis and treatment of lung cancer, as well as the challenges of exploiting HOTAIR for intervention of lung cancer.
长链非编码RNA（lncRNAs）调控着基本的生物化学和细胞过程。lncRNA HOX转录本反义RNA（HOTAIR）通过招募染色质修饰因子来抑制基因表达。HOTAIR在肺癌中的表达升高，且与转移和不良预后相关。此外，HOTAIR促进肺癌细胞的增殖、存活、侵袭、转移及耐药性。在此，我们综述了HOTAIR介导肺癌侵袭性表型的分子机制。我们还讨论了HOTAIR在肺癌诊断和治疗中的潜力，以及利用HOTAIR干预肺癌所面临的挑战。
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