Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, 250062, China.
Shandong Xinchuang Biotechnology Co., LTD, Jinan, 250102, China.
Cancer Lett. 2019 May 28;450:14-21. doi: 10.1016/j.canlet.2019.02.036. Epub 2019 Feb 23.
Homeobox (HOX) genes play vital roles in embryonic development and oncogenesis. In humans, there are 39 HOX genes found in four clusters that are located on different chromosomes. The HOX clusters also contain numerous non-protein-coding RNAs, including some lncRNAs. The HOX cluster-embedded lncRNAs (HOX-lncRNAs), most notably, HOTTIP and HOTAIR play a major role in the regulation of their adjacent coding genes. Recently, most HOX-lncRNAs have been shown to impact tumorigenesis and cancer progression. Several HOX-lncRNAs, including HOTTIP, HOXA11-AS, HOTAIRM1, HOXA-AS3, HOXA10-AS, HOTAIR, and HAGLR, are dysregulated in lung cancer. Moreover, their expression levels are correlated with the clinical features of this disease. These HOX-lncRNAs regulate the proliferation, invasion, migration, and chemo-resistance of lung cancer cells through various molecular mechanisms. Although lncRNAs have received much attention lately, the functions of some HOX-lncRNAs in the development of cancer are unclear. Thus, HOX-embedded lncRNAs should be widely investigated in cancer. Here, we review the functions of HOX-lncRNAs in lung cancer.
同源盒（HOX）基因在胚胎发育和肿瘤发生中起着至关重要的作用。在人类中，有 39 个 HOX 基因位于四个簇中，位于不同的染色体上。HOX 簇还包含许多非蛋白编码 RNA，包括一些长链非编码 RNA。HOX 簇内嵌入的长链非编码 RNA（HOX-lncRNAs），尤其是 HOTTIP 和 HOTAIR，在调节其相邻编码基因方面发挥着重要作用。最近，大多数 HOX-lncRNAs 已被证明对肿瘤发生和癌症进展有影响。一些 HOX-lncRNAs，包括 HOTTIP、HOXA11-AS、HOTAIRM1、HOXA-AS3、HOXA10-AS、HOTAIR 和 HAGLR，在肺癌中失调。此外，它们的表达水平与该疾病的临床特征相关。这些 HOX-lncRNAs 通过各种分子机制调节肺癌细胞的增殖、侵袭、迁移和化疗耐药性。尽管长链非编码 RNA 最近受到了广泛关注，但一些 HOX-lncRNAs 在癌症发展中的功能尚不清楚。因此，HOX 嵌入的 lncRNAs 应该在癌症中广泛研究。在这里，我们综述了 HOX-lncRNAs 在肺癌中的功能。
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