Zanoni R, Ioannidu C A, Mazzola L, Politi L, Misiano C, Longo G, Falconieri M, Scandurra R
Dipartimento di Chimica, Università di Roma 'La Sapienza' p.le Aldo Moro 5, 00185 Rome, Italy.
Dipartimento di Scienze Biochimiche, Università di Roma 'La Sapienza', p.le Aldo Moro 5, 00185 Rome, Italy.
Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:409-16. doi: 10.1016/j.msec.2014.10.073. Epub 2014 Oct 28.
A nanostructured coating layer on titanium implants, able to improve their integration into bones and to protect against the harsh conditions of body fluids, was obtained by Ion Plating Plasma Assisted, a method suitable for industrial applications. A titanium carbide target was attached under vacuum to a magnetron sputtering source powered with a direct current in the 500-1100 W range, and a 100 W radio frequency was applied to the sample holder. The samples produced at 900 W gave the best biological response in terms of overexpression of some genes of proteins involved in bone turnover. We report the characterization of a reference and of an implant sample, both obtained at 900 W. Different micro/nanoscopic techniques evidenced the morphology of the substrates, and X-ray Photoelectron Spectroscopy was used to disclose the surface composition. The layer is a 500 nm thick hard nanostructure, composed of 60% graphitic carbon clustered with 15% TiC and 25% Ti oxides.
通过离子镀等离子体辅助技术在钛植入物上获得了一层纳米结构涂层，该涂层能够改善植入物与骨骼的结合，并抵御体液的恶劣环境，这是一种适用于工业应用的方法。在真空中将碳化钛靶材连接到一个由500 - 1100瓦范围内的直流电供电的磁控溅射源上，并向样品架施加100瓦的射频功率。在900瓦功率下制备的样品在参与骨转换的某些蛋白质基因的过表达方面表现出最佳的生物学反应。我们报告了在900瓦功率下获得的一个参考样品和一个植入物样品的表征情况。不同的微观/纳米技术证实了基底的形态，并用X射线光电子能谱来揭示表面成分。该涂层是一个500纳米厚的硬纳米结构，由60%的石墨碳与15%的碳化钛和25%的钛氧化物聚集而成。
