Welter Evelyn, Elazar Zvulun
Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel.
EMBO J. 2015 Jan 13;34(2):131-3. doi: 10.15252/embj.201490621. Epub 2014 Dec 9.
During nitrogen starvation, a nonselective bulk degradation of cytosolic proteins and organelles including ribosomes, termed macro‐autophagy (hereafter termed autophagy), is induced. The precise mechanism of RNA degradation by this pathway has not been yet elucidated. In this issue of the The EMBO Journal, Huang et al characterize an autophagy‐dependent RNA catabolism in yeast and identify the enzymes responsible for the degradation process.
在氮饥饿期间,会诱导细胞溶质蛋白和包括核糖体在内的细胞器进行非选择性的大量降解,即巨自噬(以下简称自噬)。该途径导致RNA降解的确切机制尚未阐明。在本期《EMBO杂志》中,黄等人描述了酵母中一种依赖自噬的RNA分解代谢,并确定了负责降解过程的酶。