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Enhancement of peripheral nerve regeneration by pharmacological activation of the cyclic AMP second messenger system.

作者信息

Klein H W, Kilmer S, Carlsen R C

机构信息

Department of Surgery, University of California School of Medicine, Davis.

出版信息

Microsurgery. 1989;10(2):122-5. doi: 10.1002/micr.1920100211.

DOI:10.1002/micr.1920100211
PMID:2549330
Abstract

This paper reviews the history of attempts to study peripheral nerve regeneration, focusing upon pharmacologic agents that may prove to be useful clinically. In particular, forskolin is described as a model for such an agent, and its mechanism of action, as a stimulator of the cyclic AMP second messenger system, is described.

摘要

相似文献

1
Enhancement of peripheral nerve regeneration by pharmacological activation of the cyclic AMP second messenger system.
Microsurgery. 1989;10(2):122-5. doi: 10.1002/micr.1920100211.
2
Chronic infusion of agents that increase cyclic AMP concentration enhances the regeneration of mammalian peripheral nerves in vivo.长期输注可增加环磷酸腺苷(cAMP)浓度的药物能增强哺乳动物外周神经在体内的再生能力。
Exp Neurol. 1987 Feb;95(2):357-67. doi: 10.1016/0014-4886(87)90144-0.
3
The second messenger, cyclic AMP, is not sufficient for myelin gene induction in the peripheral nervous system.第二信使环磷酸腺苷(cAMP)不足以在外周神经系统中诱导髓鞘基因。
J Neurochem. 1995 Jul;65(1):149-59. doi: 10.1046/j.1471-4159.1995.65010149.x.
4
Forskolin activation of adenylate cyclase in vivo stimulates nerve regeneration.福司可林在体内激活腺苷酸环化酶可刺激神经再生。
Nature. 1984;307(5950):455-7. doi: 10.1038/307455a0.
5
Astroglial membrane structure is affected by agents that raise cyclic AMP and by phosphatidylcholine phospholipase C.星形胶质细胞膜结构受提高环磷酸腺苷的物质和磷脂酰胆碱磷脂酶C的影响。
J Neurocytol. 1992 Jun;21(6):458-67. doi: 10.1007/BF01191509.
6
Pharmacologic enhancement of functional recovery in free muscle transfers.游离肌肉移植中功能恢复的药理学增强
J Reconstr Microsurg. 1988 Jul;4(4):277-81, 283-4. doi: 10.1055/s-2007-1006932.
7
Beta 2-adrenergic receptors on peripheral nerves.
J Neurochem. 1986 Jan;46(1):294-6. doi: 10.1111/j.1471-4159.1986.tb12961.x.
8
Participation of cyclic adenosine monophosphate and beta-adrenergic receptors in the facilitatory effect of noradrenaline on the response of cultured cerebellar neurons to glutamate.环磷酸腺苷和β-肾上腺素能受体在去甲肾上腺素对培养小脑神经元谷氨酸反应的易化作用中的参与。
Brain Res. 1989 Jun 19;490(1):64-72. doi: 10.1016/0006-8993(89)90431-9.
9
Cyclic AMP regulation of messenger RNA level of the stimulatory GTP-binding protein Gs alpha. Isoproterenol, forskolin and 8-bromoadenosine 3':5'-cyclic monophosphate increase the level of Gs alpha mRNA in cultured astroglial cells.环磷酸腺苷对刺激性鸟苷结合蛋白Gsα信使核糖核酸水平的调节。异丙肾上腺素、福斯高林和8-溴腺苷3':5'-环一磷酸可提高培养的星形胶质细胞中Gsα信使核糖核酸的水平。
Eur J Biochem. 1994 Jan 15;219(1-2):529-37. doi: 10.1111/j.1432-1033.1994.tb19968.x.
10
Accelerating axon growth to overcome limitations in functional recovery after peripheral nerve injury.加速轴突生长以克服周围神经损伤后功能恢复的限制。
Neurosurgery. 2009 Oct;65(4 Suppl):A132-44. doi: 10.1227/01.NEU.0000335650.09473.D3.

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Histological examination of the effects of epidermal growth factor on regeneration of acute peripheral nerve injuries on rabbit model.表皮生长因子对兔急性周围神经损伤再生影响的组织学观察。
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Deep Sequencing Reveals the Significant Involvement of cAMP-Related Signaling Pathways Following Sciatic Nerve Crush.
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Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells.血小板衍生生长因子和成纤维细胞生长因子是大鼠雪旺细胞的促有丝分裂原。
J Cell Biol. 1990 Apr;110(4):1353-60. doi: 10.1083/jcb.110.4.1353.