Klein H W, Carlsen R C, Gourley I
Division of Plastic and Reconstructive Surgery, University of California, Davis, Sacramento 95817.
J Reconstr Microsurg. 1988 Jul;4(4):277-81, 283-4. doi: 10.1055/s-2007-1006932.
To date, most free muscle transfers have been marginally successful as functioning units, producing no more than 50 percent of the tension generated by an identical non-transferred muscle. Functional recovery depends both on revascularization and re-innervation, even after careful microvascular anastomosis, remains limited. Forskolin is a robust stimulator of adenylate cyclase and has been used to stimulate peripheral nerve regeneration in vivo; Forskolin may also directly increase capillary growth. Chronic infusion of Forskolin for the first 21 days following orthotopic transplantation of rabbit rectus femoris, with neurovascular anastomosis, stimulated a two-fold increase in the force-generating capacity of the transplant nine to 10 months after surgery. These results, in a model similar to clinical free muscle transfer, offer promise that Forskolin treatment can improve functional recovery by improving muscle re-innervation.
迄今为止，作为功能单位，大多数游离肌肉移植的成功率都很有限，所产生的张力不超过相同未移植肌肉的50%。功能恢复既取决于血管再通，也取决于神经再支配，即使经过仔细的微血管吻合，功能恢复仍然有限。福斯可林是腺苷酸环化酶的强效刺激剂，已被用于体内刺激周围神经再生；福斯可林还可能直接促进毛细血管生长。在兔股直肌原位移植并进行神经血管吻合后的头21天持续输注福斯可林，可使术后9至10个月移植肌肉的产力能力提高两倍。在一个类似于临床游离肌肉移植的模型中，这些结果表明福斯可林治疗有望通过改善肌肉神经再支配来提高功能恢复。
