西非和中非分枝杆菌种群的变化及新出现的耐药性
Shifts in Mycobacterial Populations and Emerging Drug-Resistance in West and Central Africa.
作者信息
Gehre Florian, Ejo Mebrat, Fissette Kristina, de Rijk Pim, Uwizeye Cécile, Nduwamahoro Elie, Goovaerts Odin, Affolabi Dissou, Gninafon Martin, Lingoupou Fanny M, Barry Mamadou Dian, Sow Oumou, Merle Corinne, Olliaro Piero, Ba Fatoumata, Sarr Marie, Piubello Alberto, Noeske Juergen, Antonio Martin, Rigouts Leen, de Jong Bouke C
机构信息
Institute of Tropical Medicine (ITM), Antwerp, Belgium; Medical Research Council (MRC), The Gambia Unit, Fajara, The Gambia.
Institute of Tropical Medicine (ITM), Antwerp, Belgium.
出版信息
PLoS One. 2014 Dec 10;9(12):e110393. doi: 10.1371/journal.pone.0110393. eCollection 2014.
In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.
在本研究中，我们回顾性分析了来自六个西非或中非国家（贝宁、喀麦隆、中非共和国、几内亚 - 科纳克里、尼日尔和塞内加尔）的总共605株临床分离株。除了通过间隔寡核苷酸分型将分离株归类为古代和现代分枝杆菌谱系外，我们还对每种分离株针对四种一线药物进行了表型药敏试验。我们发现，系统发育上的现代结核分枝杆菌菌株比古代菌株更易与耐药性相关，并预测目前在西非/中非地区正在发生的地方性古代分枝杆菌群体被现代分枝杆菌群体取代的情况可能会导致该次区域耐药性增加。
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