Bilinski Tomasz, Zadrag-Tecza Renata
Department of Biochemistry and Cell Biology, University of Rzeszow, Rzeszów, Poland.
Acta Biochim Pol. 2014;61(4):663-9. Epub 2014 Dec 11.
The success of experimental biology was possible due to the use of model organisms. It is believed that the mechanisms of aging have a universal character and they are conserved in a wide range of organisms. The explanation of these universal mechanisms by tracing survival curves of model organisms clearly suggests that death of individuals is a direct consequence of aging. Furthermore, the use of unicellular organisms like yeast Saccharomyces cerevisiae to explain the aging processes of multicellular organisms runs the risk of oversimplification. Aging is a very complex process and therefore in this paper we present arguments suggesting that some of these fundamental assumptions require a deep rethinking and verification.
实验生物学的成功得益于模式生物的使用。人们认为衰老机制具有普遍特征，并且在广泛的生物体中是保守的。通过追踪模式生物的生存曲线来解释这些普遍机制，清楚地表明个体死亡是衰老的直接后果。此外，使用单细胞生物如酿酒酵母来解释多细胞生物的衰老过程存在过度简化的风险。衰老是一个非常复杂的过程，因此在本文中，我们提出一些观点，表明其中一些基本假设需要深入反思和验证。
