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肥大假说作为酵母复制性衰老现象的另一种解释。

Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeast.

机构信息

Department of Biochemistry and Cell Biology, University of Rzeszów, Rzeszów, Poland.

出版信息

FEMS Yeast Res. 2012 Feb;12(1):97-101. doi: 10.1111/j.1567-1364.2011.00759.x. Epub 2011 Nov 28.

DOI:10.1111/j.1567-1364.2011.00759.x
PMID:22093953
Abstract

This paper summarizes numerous arguments demonstrating that the hypothesis of accumulation of the senescence factor, which was the basis for introducing yeast to the group of model organisms of gerontology, finds no experimental support. Among several candidates for the role of the causative agents of replicative aging, only one - hypertrophy - always accompanies symptoms of aging, not only in Saccharomyces cerevisiae, but also in Schizosaccharomyces pombe.

摘要

本文总结了众多论点，表明衰老因子积累的假设，该假设是将酵母引入衰老生物学模型生物群体的基础，没有得到实验支持。在几种可能导致复制性衰老的候选因素中，只有一种——肥大——总是伴随着衰老症状，不仅在酿酒酵母中，而且在裂殖酵母中也是如此。

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