Brashishkite D A, Tatosian A G, Kiselev F L, Kashleva E A, Deĭchman G I
Mol Biol (Mosk). 1989 May-Jun;23(3):758-64.
The structure of provirus in Syrian hamster cells, transformed by Rous sarcoma virus (RSV) varying in metastatic capability in vivo has been analysed. The original cell line and its low metastatic variants contain only one copy of the integrated RSV genome. The DNA of highly metastatic cell lines cloned from the same primary culture, contain an additional copy of provirus. This RSV copy in different highly metastatic variants has a similar integration site.
对经劳斯肉瘤病毒（RSV）转化的叙利亚仓鼠细胞中前病毒的结构进行了分析，这些细胞在体内的转移能力各不相同。原始细胞系及其低转移变体仅含有一个整合的RSV基因组拷贝。从同一原代培养物中克隆的高转移细胞系的DNA含有一个额外的前病毒拷贝。不同高转移变体中的这个RSV拷贝具有相似的整合位点。
