Jen L S, Zhao L P, Chau R M
Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong.
Neurosci Lett. 1989 Aug 28;103(2):133-8. doi: 10.1016/0304-3940(89)90564-8.
The present study has investigated the cytochrome oxidase (CO) activity in retinas of normal rats and rats which received central lesions at birth or young adult stage. The results show that a thalamic lesion which injured the retinal ganglion cell axons in young adult rats led to severe loss of CO activity in the ganglion, inner and outer plexiform layers in the retina contralateral to the lesion as compared to those of normal rats. In contrast, distinct CO-reactive bands and cells were clearly observed in corresponding laminae in retinas in which almost the entire population of retinal ganglion cells was eliminated by a neonatal thalamic lesion. These results indicate that retinal ganglion cells contribute significantly to the CO activity observed in the inner retinal laminae under normal but not under abnormal conditions, and suggest that considerable changes in the activity of the remaining neurons and possibly reorganization of neural circuitry within the retina in rats which received neonatal lesions has taken place, as revealed by CO histochemistry.
本研究调查了正常大鼠以及在出生时或成年早期接受中枢损伤的大鼠视网膜中的细胞色素氧化酶（CO）活性。结果表明，成年幼鼠的丘脑损伤若损伤了视网膜神经节细胞轴突，与正常大鼠相比，损伤对侧视网膜的神经节层、内网状层和外网状层中的CO活性会严重丧失。相比之下，在几乎所有视网膜神经节细胞都被新生丘脑损伤消除的视网膜相应层中，清晰地观察到了明显的CO反应带和细胞。这些结果表明，在正常而非异常条件下，视网膜神经节细胞对视网膜内层中观察到的CO活性有显著贡献，并且表明，通过CO组织化学揭示，接受新生期损伤的大鼠视网膜中剩余神经元的活性发生了相当大的变化，并且可能发生了神经回路的重组。
