Shankaranarayana Rao B S, Ramamohan Y, Singh Y K, Dhingra N K, Raju T R
Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Hosur Road, 560029, Bangalore, India.
Brain Res Dev Brain Res. 2000 Nov 30;124(1-2):117-20. doi: 10.1016/s0165-3806(00)00092-4.
In this study, the metabolic activity of rat retinal ganglion cells during postnatal development has been examined in vivo using cytochrome oxidase histochemistry. The intensity of staining was measured by optical densitometry. The activity of cytochrome oxidase in retinal ganglion cells progressively increased from postnatal day 0 (P0) and reached a peak during the second week of postnatal development (P10-P14) and declined thereafter. Our data show that the increased levels of cytochrome oxidase seen in developing retinal ganglion cells occur at the same time, when neuronal maturity and synaptogenesis reach their peaks.
在本研究中，利用细胞色素氧化酶组织化学方法在体内检测了大鼠视网膜神经节细胞在出生后发育过程中的代谢活性。染色强度通过光密度测定法进行测量。视网膜神经节细胞中细胞色素氧化酶的活性从出生后第0天（P0）开始逐渐增加，并在出生后发育的第二周（P10 - P14）达到峰值，此后下降。我们的数据表明，发育中的视网膜神经节细胞中细胞色素氧化酶水平的增加与神经元成熟和突触形成达到峰值的时间相同。
