Dunnington E A, Siegel P B, Ehrich M
Poultry Science Department, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Neurotoxicology. 1989 Spring;10(1):71-8.
Neurotoxicity of diisopropyl phosphorofluoridate (DFP) was examined at 85 weeks of age in hens of two lines selected for high (HA) and low (LA) antibody response to sheep erythrocytes. DFP was administered by subcutaneous injection in doses of 0.25, 0.50 and 1.00 mg/kg and hens were observed for cholinergic signs at 30 min and for delayed neuropathy 8 to 14 days post-administration. Toxicity to DFP increased in severity with the dose and genetic differences were present because hens of line HA were more sensitive to DFP than were those of line LA. HA hens also had lower A-esterase activities and higher heterophil-to-lymphocyte ratios. No line x treatment interaction was evident, however, for activities of neurotoxic esterase or brain cholinesterase measured 24 hr after DFP administration.
在85周龄时，对选择出的对绵羊红细胞具有高（HA）和低（LA）抗体反应的两个品系母鸡，检测了二异丙基氟磷酸酯（DFP）的神经毒性。以0.25、0.50和1.00 mg/kg的剂量通过皮下注射给予DFP，并在给药后30分钟观察母鸡的胆碱能体征，在给药后8至14天观察迟发性神经病。对DFP的毒性随着剂量增加而严重程度增加，并且存在遗传差异，因为HA品系的母鸡比LA品系的母鸡对DFP更敏感。HA品系母鸡的A酯酶活性也较低，而异嗜性粒细胞与淋巴细胞的比例较高。然而，在DFP给药24小时后测量的神经毒性酯酶或脑胆碱酯酶活性方面，没有明显的品系×处理交互作用。
