Kellner T P, Henderson J D, Higgins R J, Wilson B W
Department of Avian Sciences and Environmental Toxicology, University of California, Davis 95616.
Neurotoxicology. 1988 Summer;9(2):181-7.
Atropine is often given as an antidote for acute cholinergic effects in studies of a delayed neuropathy (OPIDN) caused by some organophosphorus esters. These experiments examined if atropine would also affect the onset and/or severity of signs of OPIDN. Chickens were given one to six 200 micrograms/kg doses of diisopropyl phosphorofluoridate (DFP) with or without 20 mg/kg atropine (IM). Locomotion, brain neurotoxic esterase (NTE) activity, and histology of the nervous system were examined. The results demonstrated that atropine treatments delayed onset of the signs of OPIDN and may have slightly increased brain NTE activity in vivo. Relatively high levels (Ki: approximately 3.0 mM) of atropine inhibited NTE activity in vitro.
在一些有机磷酸酯所致迟发性神经病（OPIDN）的研究中，阿托品常作为急性胆碱能效应的解毒剂使用。这些实验研究了阿托品是否也会影响OPIDN体征的出现和/或严重程度。给鸡注射一至六剂200微克/千克的二异丙基氟磷酸酯（DFP），有或没有20毫克/千克的阿托品（肌肉注射）。检测了鸡的运动能力、脑神经毒性酯酶（NTE）活性以及神经系统组织学。结果表明，阿托品治疗延迟了OPIDN体征的出现，并且可能在体内略微增加了脑NTE活性。相对较高水平（Ki：约3.0 mM）的阿托品在体外抑制NTE活性。
