Xu Wang Hong, Xiang Yong-Bing, Zhang Xianglan, Ruan Zhixian, Cai Hui, Zheng Wei, Shu Xiao-Ou
a Department of Epidemiology, School of Public Health , Fudan University , Shanghai , People's Republic of China.
Nutr Cancer. 2015;67(1):89-97. doi: 10.1080/01635581.2015.976319. Epub 2014 Dec 12.
We evaluated the association of dietary glycemic index (GI) and glycemic load (GL) with the risk of endometrial cancer in a population-based, case-control study of 1199 endometrial cancer patients and 1212 age-frequency-matched controls in urban Shanghai, China, where diets are typically high in carbohydrates and have a high GL. Information on dietary habits, physical activity, and other relevant information was collected using a validated questionnaire, and anthropometric measurements were taken. Logistic regression was applied in the analysis. Dietary GI and GL were independently associated with risk for endometrial cancer but carbohydrate intake was unrelated to risk. Multivariable-adjusted odds ratios (ORs) for increasing quartiles of intake were 1.0, 1.3, 1.4, and 2.2 [95% confidence interval (CI): 1.2-4.0] for dietary GL (P(trend) = 0.02) and 1.0, 1.2, 1.4, and 1.4 (95% CI: 1.0-2.0) for dietary GI (P(trend) = 0.02). High intake of staples, especially rice, was positively associated with endometrial cancer. The association with GI was more evident among lean and normal weight women, although the test for interaction was not significant. This study suggests that intake of high GL or GI foods, but not carbohydrates per se, may increase risk for endometrial cancer.
在一项基于人群的病例对照研究中，我们评估了饮食血糖生成指数（GI）和血糖负荷（GL）与子宫内膜癌风险之间的关联。该研究在中国上海市区开展，纳入了1199例子宫内膜癌患者和1212例年龄及频率匹配的对照，当地饮食通常碳水化合物含量高且GL也高。通过一份经验证有效的问卷收集饮食习惯、身体活动及其他相关信息，并进行人体测量。分析采用逻辑回归。饮食GI和GL与子宫内膜癌风险独立相关，但碳水化合物摄入量与风险无关。饮食GL摄入量增加的四分位数对应的多变量调整比值比（OR）分别为1.0、1.3、1.4和2.2 [95%置信区间（CI）：1.2 - 4.0]（P趋势 = 0.02），饮食GI对应的OR分别为1.0、1.2、1.4和1.4（95% CI：1.0 - 2.0）（P趋势 = 0.02）。主食尤其是大米的高摄入量与子宫内膜癌呈正相关。在体重偏瘦和正常的女性中，与GI的关联更为明显，尽管交互作用检验无显著性差异。本研究表明，摄入高GL或GI的食物，而非碳水化合物本身，可能会增加子宫内膜癌风险。
