膳食血糖生成指数、血糖负荷和碳水化合物与宫颈上皮内瘤变和宫颈癌风险的关联：病例对照研究。

Associations of Dietary Glycemic Index, Glycemic Load and Carbohydrate with the Risk of Cervical Intraepithelial Neoplasia and Cervical Cancer: A Case-Control Study.

机构信息

Division of Cancer Epidemiology and Prevention, National Cancer Center, Ilsandong-gu, Goyang-si 10408, Korea.

Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang-si 10408, Korea.

出版信息

Nutrients. 2020 Dec 4;12(12):3742. doi: 10.3390/nu12123742.

DOI:10.3390/nu12123742

PMID:33291721

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7761966/

Abstract

BACKGROUND

The association of dietary glycemic index (GI) and glycemic load (GL) with the risk of cervical cancer has never been investigated. Thus, we aimed to find evidence of any association of GI and GL with the risk of cervical intraepithelial neoplasia (CIN) and cervical cancer.

METHODS

In this hospital-based case-control study, we included 1340 women (670 controls and 262, 187 and 221 patients with CIN1, CIN2/3, and cervical cancer, respectively) from the Korean human papillomavirus cohort study. Completed demographic questionnaires and semi-quantitative food-frequency questionnaires were collected. The association of dietary GI and GL with CIN and cervical cancer was estimated using a logistic regression model.

RESULTS

The multivariate odds ratios (OR) of the highest compared with the lowest quintile of GL for CIN1 were 2.8 (95% confidence interval (CI) = 1.33-5.88). Dietary GI and GL were not associated with CIN2/3 and cervical cancer. Stratified analyses by body mass index (BMI) indicated a positive association between GI and GL and CIN 1 risk among women with a BMI (in kg/m) <23 (OR = 2.94; 95% CI = 1.32-6.53; for trend = 0.031 for GI and OR = 3.15; 95% CI = 1.53-6.52; for trend = 0.013 for GL), but not among those with a BMI of ≥23. A stratification analysis by menopausal status showed that the highest quintile of GI and GL was significantly associated with the risk of CIN1 (OR = 2.91; 95% CI = 1.43-5.96; for trend = 0.005) (OR = 2.96; 95% CI = 1.53-5.69; for trend = 0.023) among premenopausal women. Also, in HPV positive women, dietary GL showed significant CIN1 risk (OR = 2.61; 95% CI = 1.09-6.24; for trend = 0.087).

CONCLUSION

Our case-control study supports the hypothesized associations of dietary GI and GL with increased risk of CIN1. Thus, the consumption of low GI and GL foods plays a significant role in the prevention of cervical carcinogenesis.

摘要

背景

饮食血糖指数（GI）和血糖负荷（GL）与宫颈癌风险的关联尚未得到研究。因此，我们旨在寻找 GI 和 GL 与宫颈上皮内瘤变（CIN）和宫颈癌风险之间任何关联的证据。

方法

在这项基于医院的病例对照研究中，我们纳入了来自韩国人乳头瘤病毒队列研究的 1340 名女性（670 名对照者和 262、187 和 221 名 CIN1、CIN2/3 和宫颈癌患者）。收集了完成的人口统计学问卷和半定量食物频率问卷。使用 logistic 回归模型估计饮食 GI 和 GL 与 CIN 和宫颈癌的关联。

结果

与 GL 最低五分位相比，GL 最高五分位的 CIN1 的多变量比值比（OR）为 2.8（95%置信区间（CI）=1.33-5.88）。GI 和 GL 与 CIN2/3 和宫颈癌无关联。按体重指数（BMI）分层分析表明，在 BMI（kg/m）<23 的女性中，GI 和 GL 与 CIN1 风险之间存在正相关（OR=2.94；95%CI=1.32-6.53；趋势 P=0.031），但在 BMI≥23 的女性中则没有。按绝经状态分层分析表明，GI 和 GL 的最高五分位与 CIN1 的风险显著相关（OR=2.91；95%CI=1.43-5.96；趋势 P=0.005）（OR=2.96；95%CI=1.53-5.69；趋势 P=0.023），在绝经前女性中。此外，在 HPV 阳性女性中，饮食 GL 与 CIN1 风险显著相关（OR=2.61；95%CI=1.09-6.24；趋势 P=0.087）。