Nowak G
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Pharmacol Toxicol. 1989 May;64(5):469-70. doi: 10.1111/j.1600-0773.1989.tb00689.x.
The effect of repeated treatment with imipramine, citalopram and ECS on the density of alpha 1-adrenoceptors in the cerebral cortex of rats with a dopaminergic lesion was studied. Imipramine and citalopram produced alph 1-upregulation in normal animals but not in animals with a dopaminergic lesion. On the other hand, ECS, produced such an effect in both normal and lesioned rats. Our results indicate that the investigated drugs (imipramine, citalopram) and ECS induce alpha 1-up-regulation via different mechanisms, and that the effect of these drugs depends on intact dopaminergic nerve terminals.
研究了用丙咪嗪、西酞普兰和电惊厥休克（ECS）反复治疗对多巴胺能损伤大鼠大脑皮质α1-肾上腺素能受体密度的影响。丙咪嗪和西酞普兰在正常动物中引起α1-上调，但在多巴胺能损伤的动物中则不然。另一方面，ECS在正常和损伤大鼠中均产生这种效应。我们的结果表明，所研究的药物（丙咪嗪、西酞普兰）和ECS通过不同机制诱导α1-上调，并且这些药物的作用取决于完整的多巴胺能神经末梢。
