[In situ hybridization in detecting virus infections in biopsies following orthotopic liver transplantation].

Using the in-situ DNA hybridization we studied 62 liver biopsies from 34 patients for the presence of CMV-, EBV-, HBV-, and HSV-Genome. In the first biopsies positivity-rates were as follows: CMV 62%, EBV 71%, HBV 15%, HSV 15%. In 6 cases a conversion from a negative intranuclear CMV-status to a positive status was seen correlating with an increase in serological titers and with clinical signs of viral infection.