Gupta Prashant, Khandpur Sujay, Vedi Kamal, Singh Manoj K, Walia Ritika
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Pediatr Dermatol. 2015 Jan-Feb;32(1):e1-4. doi: 10.1111/pde.12388. Epub 2014 Dec 14.
Xanthoma disseminatum (XD) is a rare, benign, non-Langerhans cell histiocytosis characterized by disseminated xanthomatous lesions with a predilection for the face, flexures, and mucosae. Approximately 100 cases have been reported in the literature. We report XD in an 8-year-old boy with symmetric synovitis and arthritis involving the wrists and knees. This case is interesting in view of the association between arthritis and synovitis and XD, which to our knowledge has not been reported in the literature. This case has to be differentiated from multicentric histiocytosis, another non-Langerhans cell histiocytosis, in which joint involvement is common.
播散性黄瘤（XD）是一种罕见的良性非朗格汉斯细胞组织细胞增生症，其特征为播散性黄瘤样病变，好发于面部、屈侧和黏膜。文献报道约100例。我们报告了1例8岁男孩患播散性黄瘤，伴有累及手腕和膝盖的对称性滑膜炎和关节炎。鉴于关节炎、滑膜炎与播散性黄瘤之间的关联，该病例很有趣，据我们所知，这在文献中尚未有报道。该病例必须与多中心组织细胞增生症相鉴别，后者是另一种非朗格汉斯细胞组织细胞增生症，关节受累很常见。
