Schoenberg J B, Wilcox H B, Mason T J, Bill J, Stemhagen A
Cancer Epidemiology Program, New Jersey State Department of Health, Trenton 08625.
Am J Epidemiol. 1989 Oct;130(4):688-95. doi: 10.1093/oxfordjournals.aje.a115390.
A population-based incident lung cancer case-control study was conducted among New Jersey women in 1982-1983. Interviews were completed for 994 cases and 995 controls. The association of lung cancer with cigarette smoking had an overall age-, race-, and respondent type-adjusted odds ratio of 8.5, with risks of 11.1, 62.6, and 3.9 for squamous cell, small cell, and adenocarcinoma, respectively. Analyses for squamous cell carcinoma showed significantly higher odds ratios for self-respondents than for subjects with next of kin respondents; this heterogeneity may be partially explained by misclassification in next of kin reports. Analyses for adenocarcinoma showed a significantly lower smoking-related risk among older women, which may be related to the later age at which these women began smoking. Analyses by histologic subtype showed lower risks for poorly differentiated squamous cell carcinoma and higher risks for poorly differentiated adenocarcinoma. This could be due to misclassification of histologic type and suggests that the actual smoking-related risk for squamous cell carcinoma might be higher than observed, and that for adenocarcinoma might be lower. Comparison of the results in this study with those from a similar study of lung cancer among men showed little difference between men and women in the magnitude of the association with smoking, or in the patterns of risk with intensity and duration.
1982 - 1983年在新泽西州女性中开展了一项基于人群的肺癌发病病例对照研究。完成了对994例病例和995名对照的访谈。肺癌与吸烟的关联在总体上经年龄、种族和应答者类型调整后的优势比为8.5，鳞状细胞癌、小细胞癌和腺癌的风险分别为11.1、62.6和3.9。鳞状细胞癌的分析显示，自我应答者的优势比显著高于由近亲应答的受试者；这种异质性可能部分是由于近亲报告中的错误分类所致。腺癌的分析显示老年女性中与吸烟相关的风险显著较低，这可能与这些女性开始吸烟的年龄较晚有关。按组织学亚型分析显示，低分化鳞状细胞癌的风险较低，低分化腺癌的风险较高。这可能是由于组织学类型的错误分类，表明鳞状细胞癌实际与吸烟相关的风险可能高于观察到的风险，而腺癌的风险可能低于观察到的风险。将本研究结果与一项类似的男性肺癌研究结果进行比较，结果显示男性和女性在与吸烟关联的程度、以及风险随强度和持续时间的模式方面几乎没有差异。
