Massaro Marina, Colletti Carmelo G, Noto Renato, Riela Serena, Poma Paola, Guernelli Susanna, Parisi Filippo, Milioto Stefana, Lazzara Giuseppe
Dipartimento STEBICEF, sez. Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
Dipartimento STEBICEF, sez. Chimica, Università di Palermo, Viale delle Scienze, Parco d'Orleans II, Ed. 17, 90128 Palermo, Italy.
Int J Pharm. 2015 Jan 30;478(2):476-85. doi: 10.1016/j.ijpharm.2014.12.004. Epub 2014 Dec 8.
Halloysite nanotubes were explored as drug carrier for cardanol, which is considered as a promising natural anticancer active species. To this aim, besides the pristine nanoclay, a chemical modification of the nanocarrier was performed by attaching triazolium salts with different hydrophobicity at the outer surface of the hollow nanotubes. The interaction between cardanol and nanotubes was highlighted in solution by HPLC. This method proved the loading of the drug into the nanotubes. The solid dried complexes formed by pristine and modified halloysite with the cardanol were characterized by IR spectroscopy, thermogravimetric analysis as well as water contact angle to evidence the structure, thermal properties and wettability of the obtained materials. The kinetics of cardanol release as well as cell viability experiments provided promising results that put forward a new strategy for potential applications of cardanol as active antiproliferative molecule and clay nanotubes as drug carrier.
埃洛石纳米管被用作腰果酚的药物载体，腰果酚被认为是一种很有前景的天然抗癌活性物质。为此，除了原始纳米粘土外，还通过在中空纳米管外表面连接不同疏水性的三唑鎓盐对纳米载体进行了化学修饰。通过高效液相色谱法（HPLC）在溶液中突出显示了腰果酚与纳米管之间的相互作用。该方法证明了药物负载到纳米管中。通过红外光谱、热重分析以及水接触角对由原始和改性埃洛石与腰果酚形成的固体干燥复合物进行了表征，以证明所得材料的结构、热性能和润湿性。腰果酚释放动力学以及细胞活力实验提供了有前景的结果，为将腰果酚作为活性抗增殖分子以及将粘土纳米管作为药物载体的潜在应用提出了一种新策略。
