Kew M C, Leckie B J, Greeff M C
Department of Medicine, Witwatersrand University Medical School, Johannesburg, South Africa.
Arch Intern Med. 1989 Sep;149(9):2111-3.
Three South African blacks with hepatocellular carcinoma and arterial hypertension are described. Plasma angiotensinogen (renin substrate) concentrations were increased eightfold to 10-fold in the two patients in whom these concentrations were measured. One of these two patients also showed a 34-fold rise in plasma inactive, active, and total renin concentrations, and an elevated plasma renin activity (2.73 ng.L-1.s-1 angiotensin l/mL/h). Inactive renin (prorenin) constituted 90% of the total plasma renin concentration. In the third patient only plasma renin activity was measured, and this was considerably raised (6.05 ng.L-1.s-1; angiotensin l/mL/h). Thus, the arterial hypertension that rarely complicates hepatocellular carcinoma may be caused either by a combination of eutopic synthesis of excessive quantities of angiotensinogen and ectopic production and secretion of active renin by malignant hepatocytes, or by eutopic production of angiotensinogen alone.
本文描述了三名患有肝细胞癌和动脉高血压的南非黑人患者。在其中两名患者中检测到血浆血管紧张素原（肾素底物）浓度增加了8倍至10倍。这两名患者中的一名还显示血浆无活性肾素、活性肾素和总肾素浓度升高了34倍，血浆肾素活性升高（2.73 ng.L-1.s-1血管紧张素I/mL/h）。无活性肾素（前肾素）占血浆总肾素浓度的90%。在第三名患者中仅测量了血浆肾素活性，该活性显著升高（6.05 ng.L-1.s-1；血管紧张素I/mL/h）。因此，很少并发肝细胞癌的动脉高血压可能是由过量血管紧张素原的原位合成与恶性肝细胞异位产生和分泌活性肾素共同作用引起的，或者仅由血管紧张素原的原位产生引起。
