Li L, Wang S J, Shi K, Chen D, Jia H, Zhu J
Department of Emergency, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Department of Emergency, The Fourth Affiliated Hospital of China Medical University, Shenyang, China
Genet Mol Res. 2014 Dec 4;13(4):10150-61. doi: 10.4238/2014.December.4.9.
Several studies have found that microsomal transfer protein (MTP) may be important in the development and progression of non-alcoholic fatty liver disease (NAFLD). In this meta-analysis, we evaluated the relationships between a common polymorphism (-493G>T, rs1800591 G>T) in the MTP gene and NAFLD risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before October 1, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Crude odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated. Eleven case-control studies were included in this meta-analysis. A total of 636 NAFLD patients and 918 healthy control subjects were examined in this meta-analysis. Our results indicate that the MTP -493G/T polymorphism increases the risk of NAFLD (G allele vs T allele: OR = 1.39, 95%CI = 1.17-1.65, P < 0.001; GG + GT vs TT: OR = 1.46, 95%CI = 1.02-2.09, P = 0.038, respectively). Subgroup analyses indicated that the MTP -493G/T polymorphism was associated with an increased risk of NAFLD in population-based, hospital-based, polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and large sample-size subgroups under the allele and dominant models (all P < 0.05). However, we found no association between non-PCR-RFLP polymorphism and small sample-size subgroups (all P > 0.05). Our findings indicate that the MTP -493G/ T polymorphism may contribute to the development of NAFLD. Thus, the MTP -493G/T polymorphism may be a biomarker for the early detection of NAFLD.
多项研究发现，微粒体转移蛋白（MTP）在非酒精性脂肪性肝病（NAFLD）的发生和发展中可能起重要作用。在这项荟萃分析中，我们评估了MTP基因中一种常见的多态性（-493G>T，rs1800591 G>T）与NAFLD风险之间的关系。检索了PubMed、CISCOM、CINAHL、科学网、谷歌学术、EBSCO、考克兰图书馆和中国生物医学文献数据库，以查找2013年10月1日前发表的相关文章，无任何语言限制。使用STATA 12.0软件进行荟萃分析。计算了粗比值比（OR）及95%置信区间（95%CI）。本荟萃分析纳入了11项病例对照研究。在此荟萃分析中，共检查了636例NAFLD患者和918例健康对照者。我们的结果表明，MTP -493G/T多态性增加了NAFLD的风险（G等位基因与T等位基因：OR = 1.39，95%CI = 1.17-1.65，P < 0.001；GG + GT与TT：OR = 1.46，95%CI = 1.02-2.09，P = 0.038）。亚组分析表明，在等位基因和显性模型下，MTP -493G/T多态性与基于人群、基于医院、聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和大样本量亚组中NAFLD风险增加相关（所有P < 0.05）。然而，我们发现非PCR-RFLP多态性与小样本量亚组之间无关联（所有P > 0.05）。我们的研究结果表明，MTP -493G/T多态性可能与NAFLD的发生有关。因此，MTP -493G/T多态性可能是NAFLD早期检测的生物标志物。
