Department of Elderly Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, P. R. China.
J Clin Lab Anal. 2016 Jan;30(1):47-57. doi: 10.1002/jcla.21814. Epub 2014 Nov 10.
Adiponectin (AdipoQ) is an adipose-derived plasma protein that plays an important role in hepatic lipoprotein-lipid metabolism. Emerging evidence have shown that two common polymorphisms (T45 G and G276 T) in the AdipoQ gene may contribute to increasing susceptibility to nonalcoholic fatty liver disease (NAFLD); however individually published studies show inconclusive results. This meta-analysis aimed to derive a more precise estimation of the association of AdipoQ T45 G (rs2241766 T>G) and G276 T (rs1501299 G>T) polymorphisms with NAFLD risk.
Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese Bio-medicine Database (CBM), and Chinese Sci-tech Journals databases. Statistical analyses were calculated using the version 12.0 STATA software (Stata Corp, College Station, TX, USA). Odds ratios (ORs) and its corresponding 95% confidence interval (CI) were calculated.
Ten case-control studies were included with a total of 2,672 subjects, of these 1,117 being NAFLD patients and 1,555 being healthy controls. Our meta-analysis results revealed that the T variant of AdipoQ rs2241766 T>G polymorphism may be associated with an increased risk of NAFLD. There was also a significant association between the G variant of AdipoQ rs1501299 G>T polymorphism and an increased risk of NAFLD. Country-stratified analysis indicated that a higher AdipoQ rs2241766 T>G polymorphism was closely related with an increased risk of NAFLD in Chinese and Indian populations (all Ps < 0.05); a similar result was observed in Chinese populations between AdipoQ rs2241766 T>G polymorphism and an increased risk of NAFLD (P < 0.05).
In conclusion, the current meta-analysis indicates that AdipoQ rs2241766 T>G and rs1501299 G>T polymorphisms may contribute to an increasing susceptibility to NAFLD. Moreover, this meta-analysis also suggests for future larger studies with stratified case-control population, and greater focus on the gene-environment interactions regarding NAFLD susceptibility for valid studies.
脂联素（AdipoQ）是一种脂肪衍生的血浆蛋白，在肝脏脂蛋白脂质代谢中发挥重要作用。新出现的证据表明，AdipoQ 基因中的两个常见多态性（T45G 和 G276T）可能导致非酒精性脂肪性肝病（NAFLD）易感性增加；然而，单独发表的研究结果并不一致。本荟萃分析旨在更准确地评估 AdipoQ T45G（rs2241766T>G）和 G276T（rs1501299G>T）多态性与 NAFLD 风险的关系。
我们检索了以下数据库中的潜在相关研究：PubMed、Embase、Web of Science、Cochrane 图书馆、中国国家知识基础设施（CNKI）、中国生物医学数据库（CBM）和中国科技期刊数据库。使用版本 12.0 STATA 软件（StataCorp，College Station，TX，USA）计算统计分析。计算比值比（ORs）及其相应的 95%置信区间（CI）。
共纳入 10 项病例对照研究，共 2672 例受试者，其中 1117 例为 NAFLD 患者，1555 例为健康对照。我们的荟萃分析结果表明，AdipoQ rs2241766T>G 多态性的 T 变体可能与 NAFLD 风险增加相关。AdipoQ rs1501299G>T 多态性的 G 变体也与 NAFLD 风险增加显著相关。基于国家的分层分析表明，较高的 AdipoQ rs2241766T>G 多态性与中国和印度人群中 NAFLD 风险增加密切相关（均 P<0.05）；在中国人群中，AdipoQ rs2241766T>G 多态性与 NAFLD 风险增加之间也观察到类似的结果（P<0.05）。
总之，本荟萃分析表明，AdipoQ rs2241766T>G 和 rs1501299G>T 多态性可能导致 NAFLD 易感性增加。此外，本荟萃分析还建议未来进行更大规模的分层病例对照人群研究，并更加关注基因-环境相互作用与 NAFLD 易感性的关系，以开展更有效的研究。
