Kiho T, Yoshida I, Nagai K, Ukai S, Hara C
Gifu Pharmaceutical University, Japan.
Carbohydr Res. 1989 Jun 15;189:273-9. doi: 10.1016/0008-6215(89)84103-5.
The structure of an alkali-soluble D-glucan (AG-AL) from the fruit body of Agrocybe cylindracea was investigated by a combination of chemical and spectroscopic methods indicating that it was a linear (1----3)-alpha-D-glucan (molecular weight, approximately 560,000), [alpha]20D +195 degrees (c 0.5, M sodium hydroxide). Both water-soluble and gelatinous products obtained by O-(carboxymethyl)ation of AG-AL showed potent antitumor activity against the solid form of Sarcoma 180 in mice, although the native D-glucan had little effect on the tumor.
采用化学和光谱方法相结合的方式，对来自柱状田头菇子实体的一种碱溶性D-葡聚糖（AG-AL）的结构进行了研究，结果表明它是一种线性（1→3）-α-D-葡聚糖（分子量约为560,000），[α]20D +195°（c 0.5，氢氧化钠溶液）。AG-AL经O-（羧甲基）化得到的水溶性和凝胶状产物，对小鼠实体瘤肉瘤180均显示出较强的抗肿瘤活性，而天然D-葡聚糖对该肿瘤几乎没有作用。
