Kang Dandan, Zhang Yu, Yu Deng-Guang, Kim Il, Song Wenliang
School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, 200093, P. R. China.
School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, P. R. China.
J Nanobiotechnology. 2025 Feb 12;23(1):101. doi: 10.1186/s12951-025-03166-8.
Polypeptides are highly valued in biomedical science for their biocompatibility and biodegradability, making them valuable in drug delivery, tissue engineering, and antibacterial dressing. The diverse design of polymer chains and self-assembly techniques allow different side chains and secondary structures, enhancing their biomedical potential. However, the traditional solid powder form of polypeptides presents challenges in skin applications, shipping, and recycling, limiting their practical utility. Recent advancements in material forming methods and polypeptide synthesis have produced biomaterials with uniform, distinct shapes, improving usability. This review outlines the progress in polypeptide synthesis and material-forming methods over the past decade. The main synthesis techniques include solid-phase synthesis and ring-opening polymerization of N-carboxyanhydrides while forming methods like electrospinning, 3D printing, and coating are explored. Integrating structural design with these methods is emphasized, leading to diverse polypeptide materials with unique shapes. The review also identifies research hotspots using VOSviewer software, which are visually presented in circular packing images. It further discusses emerging applications such as drug delivery, wound healing, and tissue engineering, emphasizing the crucial role of material shape in enhancing performance. The review concludes by exploring future trends in developing distinct polypeptide shapes for advanced biomedical applications, encouraging further research.
多肽因其生物相容性和生物可降解性在生物医学科学中具有很高的价值，这使其在药物递送、组织工程和抗菌敷料方面具有重要意义。聚合物链的多样设计和自组装技术允许形成不同的侧链和二级结构，增强了它们在生物医学方面的潜力。然而，传统的多肽固体粉末形式在皮肤应用、运输和回收方面存在挑战，限制了它们的实际应用。材料成型方法和多肽合成方面的最新进展已经产生了具有均匀、独特形状的生物材料，提高了其可用性。本综述概述了过去十年中多肽合成和材料成型方法的进展。主要合成技术包括固相合成和N-羧基酸酐的开环聚合，同时探讨了如静电纺丝、3D打印和涂层等成型方法。强调了将结构设计与这些方法相结合，从而产生具有独特形状的多样多肽材料。本综述还使用VOSviewer软件确定了研究热点，并以圆形堆积图像的形式直观呈现。它进一步讨论了药物递送、伤口愈合和组织工程等新兴应用，强调了材料形状在提高性能方面的关键作用。综述最后探讨了为先进生物医学应用开发独特多肽形状的未来趋势，鼓励进一步研究。
