Cho Hyunah, Lai Tsz Chung, Tomoda Keishiro, Kwon Glen S
Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, Missouri, 63110-1088, USA,
AAPS PharmSciTech. 2015 Feb;16(1):10-20. doi: 10.1208/s12249-014-0251-3. Epub 2014 Dec 11.
Drug combinations are common in cancer treatment and are rapidly evolving, moving beyond chemotherapy combinations to combinations of signal transduction inhibitors. For the delivery of drug combinations, i.e., multi-drug delivery, major considerations are synergy, dose regimen (concurrent versus sequential), pharmacokinetics, toxicity, and safety. In this contribution, we review recent research on polymeric micelles for multi-drug delivery in cancer. In concurrent drug delivery, polymeric micelles deliver multi-poorly water-soluble anticancer agents, satisfying strict requirements in solubility, stability, and safety. In sequential drug delivery, polymeric micelles participate in pretreatment strategies that "prime" solid tumors and enhance the penetration of secondarily administered anticancer agent or nanocarrier. The improved delivery of multiple poorly water-soluble anticancer agents by polymeric micelles via concurrent or sequential regimens offers novel and interesting strategies for drug combinations in cancer treatment.
药物联合在癌症治疗中很常见且发展迅速，已从化疗联合发展到信号转导抑制剂联合。对于药物联合给药，即多药递送，主要考虑因素包括协同作用、给药方案（同时给药与序贯给药）、药代动力学、毒性和安全性。在本论文中，我们综述了近期关于聚合物胶束用于癌症多药递送的研究。在同时给药中，聚合物胶束递送多种水溶性差的抗癌药物，满足了在溶解性、稳定性和安全性方面的严格要求。在序贯给药中，聚合物胶束参与预处理策略，使实体瘤“致敏”，并增强随后给药的抗癌药物或纳米载体的渗透。聚合物胶束通过同时或序贯给药方案改善多种水溶性差的抗癌药物的递送，为癌症治疗中的药物联合提供了新颖且有趣的策略。
