Galera-Davidson H, Fernandez A, Navarro J, Parrilla A, Salguero M, Rivera F
Department of Pathology, University of Seville, Spain.
Diagn Cytopathol. 1989;5(2):150-3. doi: 10.1002/dc.2840050208.
Seven cases of endometrial mucinous metaplasia and five of well-differentiated mucinous adenocarcinoma of the endometrium were studied. Cytologic specimens were obtained by Isaacs endometrial sampler, avoiding endocervical contamination. The histologic diagnosis between the intermediate type of mucinous metaplasia and the well-differentiated mucinous adenocarcinoma posed no problems. DNA analyses of the histologic samples showed a euploid pattern in benign and intermediate types of metaplasia, while well-differentiated mucinous adenocarcinoma showed a hyperdiploid pattern. The cytologic diagnosis of benign mucinous metaplasia should be suggested in the presence of abundant mucinous cells in endometrial samples in the absence of nuclear abnormalities.
对7例子宫内膜黏液化生和5例高分化子宫内膜黏液腺癌进行了研究。通过艾萨克斯子宫内膜取样器获取细胞学标本，避免宫颈管污染。黏液化生中间型与高分化黏液腺癌之间的组织学诊断不存在问题。组织学样本的DNA分析显示，良性和中间型化生呈整倍体模式，而高分化黏液腺癌呈超二倍体模式。在子宫内膜样本中存在大量黏液细胞且无核异常的情况下，应提示良性黏液化生的细胞学诊断。
