Lim Ju Yong, Choi Jin Oh, Oh Jae Kon, Li Zhou, Park Soon J
Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, USA; Asan Medical Center, Seoul, Korea.
Circ J. 2015;79(2):375-80. doi: 10.1253/circj.CJ-14-0672. Epub 2014 Dec 15.
Patients with severe aortic stenosis (AS) are often found to have asymmetric septal hypertrophy (ASH). With low sensitivity of echocardiography for detecting dynamic left ventricular outflow tract (LVOT) obstruction in severe AS, we adopted a routine intraoperative inspection of LVOT strategy for aortic valve replacement (AVR), and performed concomitant septal myectomy (CSM) as necessary. We sought to (1) evaluate surgical outcomes of CSM, (2) suggest preoperative echocardiographic parameters that correlate with findings of ASH, and (3) determine the predictors of CSM.
A single surgeon performed AVR for moderate-to-severe AS in 301 patients from 2007 to 2012. CSM was performed in 35 (11.6%) patients, resulting in AVR vs. AVR+CSM groups. Echocardiographic parameters, including the ratio of LVOT to aortic annular diameter (LVOT/AA), were compared. Mortality rate was comparable between groups (P=0.37). There were no postoperative complications related to CSM. The AVR+CSM group had a smaller LVOT/AA ratio (P=0.0012). The predictor of CSM was implanted valve size ≤ 21 mm (odds ratio 3.2, confidence interval 1.54-6.65, P=0.002).
CSM can be performed safely at the time of AVR. The preoperative echocardiographic LVOT/AA ratio may help in detecting ASH. As an implanted valve size ≤ 21 mm was the only risk factor for CSM, careful assessment of LVOT is important in patients with a small aortic annulus.
重度主动脉瓣狭窄(AS)患者常伴有不对称性室间隔肥厚(ASH)。由于超声心动图检测重度AS患者动态左心室流出道(LVOT)梗阻的敏感性较低,我们采用了主动脉瓣置换术(AVR)中常规的LVOT检查策略,并在必要时进行同期室间隔心肌切除术(CSM)。我们旨在:(1)评估CSM的手术效果;(2)提出与ASH表现相关的术前超声心动图参数;(3)确定CSM的预测因素。
2007年至2012年,一名外科医生为301例中重度AS患者实施了AVR。35例(11.6%)患者进行了CSM,形成了AVR组与AVR+CSM组。比较了包括LVOT与主动脉瓣环直径比值(LVOT/AA)在内的超声心动图参数。两组的死亡率相当(P=0.37)。没有与CSM相关的术后并发症。AVR+CSM组的LVOT/AA比值较小(P=0.0012)。CSM的预测因素是植入瓣膜尺寸≤21mm(比值比3.2,置信区间1.54-6.65,P=0.002)。
CSM可在AVR时安全进行。术前超声心动图LVOT/AA比值可能有助于检测ASH。由于植入瓣膜尺寸≤21mm是CSM的唯一危险因素,因此对于主动脉瓣环较小的患者,仔细评估LVOT很重要。