Centre for Cancer Biomedicine, Faculty of Medicine, Oslo University Hospital, Montebello Oslo, Norway Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Montebello Oslo, Norway.
EMBO J. 2015 Jan 13;34(2):136-7. doi: 10.15252/embj.201490707. Epub 2014 Dec 12.
Endosomes are known to undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. A recent paper (Rowland et al, 2014) shows that contact sites between endosomes and the endoplasmic reticulum (ER) define the position and timing for fission. This uncovers an unanticipated role for the ER in controlling endosomal sorting and maturation.
内体已知会发生出芽和裂变反应,将注定要溶酶体降解的区域与要回收至质膜的载体分离。最近的一篇论文(Rowland 等人,2014 年)表明,内体与内质网(ER)之间的接触位点决定了裂变的位置和时间。这揭示了 ER 在控制内体分拣和成熟中的意外作用。