Henry Wellcome Integrated Signalling Laboratories, School of Biochemistry, Medical Sciences Building, University Walk, University of Bristol, Bristol, BS8 1TD, UK.
Nat Cell Biol. 2011 Dec 22;14(1):29-37. doi: 10.1038/ncb2374.
Sorting nexins are a large family of evolutionarily conserved phosphoinositide-binding proteins that have fundamental roles in orchestrating cargo sorting through the membranous maze that is the endosomal network. One ancient group of complexes that contain sorting nexins is the retromer. Here we discuss how retromer complexes regulate endosomal sorting, and describe how this is generating exciting new insight into the central role played by endosomal sorting in development and homeostasis of normal tissues.
分选连接蛋白是一大类进化上保守的磷酸肌醇结合蛋白，它们在通过包含分选连接蛋白的古老复合物之一是逆行转运复合体（retromer）。在这里，我们讨论了逆行转运复合体如何调节内体分选，并描述了这如何为内体分选在正常组织的发育和稳态中的核心作用提供了令人兴奋的新见解。
