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IL-13 多态性与儿童哮喘风险的荟萃分析。

A meta-analysis of IL-13 polymorphisms and pediatric asthma risk.

机构信息

Department of Pediatrics, Jinan Maternal and Child Health Hospital, Shandong University, Jinan, Shandong, China (mainland).

Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (mainland).

出版信息

Med Sci Monit. 2014 Dec 11;20:2617-23. doi: 10.12659/MSM.891017.

Abstract

BACKGROUND

IL13-1112C/T and +2044A/G polymorphisms have been reported to be correlated with pediatric asthma susceptibility, but study results were still debatable. Thus, a meta-analysis was conducted.

MATERIAL/METHODS: PubMed and EMBASE databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model or fixed-effects model.

RESULTS

Fourteen case-control studies with 4710 asthma cases and 6086 controls were included in this meta-analysis. IL13-1112C/T and +2044A/G polymorphisms were significantly associated with an increased risk of pediatric asthma (OR=1.14, 95% CI 1.01-1.28, P=0.04, I2=0%; OR=1.20, 95% CI 1.09-1.32, P<0.01, I2=0%), respectively. In the subgroup analysis by ethnicity, IL13-1112C/T polymorphism was significantly associated with pediatric asthma risk in whites (OR=1.29, 95% CI 1.02-1.63, P=0.03, I2=16%). IL13 +2044A/G polymorphism was significantly associated with pediatric asthma risk in Asians (OR=1.21, 95% CI 1.10-1.34, P<0.01, I2=24%).

CONCLUSIONS

The results of this meta-analysis suggest that IL13-1112C/T and +2044A/G polymorphisms contribute to the development of pediatric asthma.

摘要

背景

IL13-1112C/T 和 +2044A/G 多态性与儿童哮喘易感性相关,但研究结果仍存在争议。因此,进行了荟萃分析。

材料/方法:检索 PubMed 和 EMBASE 数据库。使用随机效应模型或固定效应模型计算优势比(OR)和 95%置信区间(CI)来计算关联强度。

结果

这项荟萃分析纳入了 14 项病例对照研究,共包括 4710 例哮喘病例和 6086 例对照。IL13-1112C/T 和 +2044A/G 多态性与儿童哮喘的发病风险显著相关(OR=1.14,95%CI 1.01-1.28,P=0.04,I2=0%;OR=1.20,95%CI 1.09-1.32,P<0.01,I2=0%)。按种族亚组分析,IL13-1112C/T 多态性与白人儿童哮喘风险显著相关(OR=1.29,95%CI 1.02-1.63,P=0.03,I2=16%)。IL13+2044A/G 多态性与亚洲儿童哮喘风险显著相关(OR=1.21,95%CI 1.10-1.34,P<0.01,I2=24%)。

结论

本荟萃分析结果表明,IL13-1112C/T 和 +2044A/G 多态性与儿童哮喘的发生有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f60d/4271802/0cf65e731d99/medscimonit-20-2617-g001.jpg

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