Department of Pediatrics, Yazd Branch, Islamic Azad University, Yazd, Iran.
Medical Student, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fetal Pediatr Pathol. 2022 Apr;41(2):259-277. doi: 10.1080/15513815.2020.1783406. Epub 2020 Jul 8.
Previous studies have provided conflicting evidence implicating the IL-13 polymorphism and pediatric asthma. Thus, we performed a meta-analysis to combine and analyze the available studies to provide more accurate conclusions. A comprehensive retrieval in PubMed, EMBASE, Web of Science, and CNKI was performed up to February 05, 2020. A total of 39 case-control studies including 15 studies with 4,968 cases and 7,091 controls were on +1923 C > T, ten studies with 3,175 cases and 2,983 controls on -1112 C > T, and 14 studies with 4,476 cases and 5,121 controls on +2044 A > G were selected. Pooled data showed that the IL-13 + 1923 C > T, -1112 C > T and +2044 A > G polymorphisms were significantly associated with risk of pediatric asthma. The IL-13 + 1923 C > T (Asians and Africans), -1112 C > T (Caucasians) and +2044 A > G (Asians) polymorphisms were more frequently associated in these ethnic groups. Our pooled data indicated that IL-13 + 1923 C > T, -1112 C > T and +2044 A > G polymorphisms were correlated with risk of pediatric asthma.
先前的研究提供了相互矛盾的证据，暗示白细胞介素-13 多态性与儿科哮喘有关。因此，我们进行了一项荟萃分析，以合并和分析现有研究，提供更准确的结论。我们在 PubMed、EMBASE、Web of Science 和中国知网进行了全面检索，检索时间截至 2020 年 2 月 5 日。共纳入 39 项病例对照研究，其中 15 项研究包括 4968 例病例和 7091 例对照，探讨了 +1923C>T、-1112C>T 和 +2044A>G 多态性；10 项研究包括 3175 例病例和 2983 例对照，探讨了 -1112C>T 多态性；14 项研究包括 4476 例病例和 5121 例对照，探讨了 +2044A>G 多态性。汇总数据显示，白细胞介素-13+1923C>T、-1112C>T 和+2044A>G 多态性与儿科哮喘的风险显著相关。白细胞介素-13+1923C>T（亚洲人和非洲人）、-1112C>T（白种人）和+2044A>G（亚洲人）多态性在这些人群中更为常见。我们的汇总数据表明，白细胞介素-13+1923C>T、-1112C>T 和+2044A>G 多态性与儿科哮喘的风险相关。
