白细胞介素-13 多态性与哮喘风险相关：一项荟萃分析。
IL-13 polymorphisms contribute to the risk of asthma: a meta-analysis.
机构信息
Central Laboratory, the First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou, People's Republic of China.
出版信息
Clin Biochem. 2012 Mar;45(4-5):285-8. doi: 10.1016/j.clinbiochem.2011.12.012. Epub 2011 Dec 24.
OBJECTIVES
The purpose of this study was to evaluate the effects of interleukin-13 (IL-13) polymorphisms on the risk of asthma using a meta-analysis.
DESIGN AND METHODS
Fifteen publications were identified by searching Pubmed, Embase, ISI, OVID, and EBSCO databases. Odds ratios with corresponding 95% confidence intervals were computed to estimate the association between IL-13 polymorphisms and risk of asthma.
RESULTS
The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses. Subgroup analyses showed that the elevated risks occurred in adult-onset asthma, Caucasians, and high quality studies.
CONCLUSIONS
This meta-analysis provides evidence that the R130Q and -1112C/T polymorphisms in IL-13 are risk factors for asthma.
目的
本研究旨在通过荟萃分析评估白细胞介素 13（IL-13）多态性对哮喘风险的影响。
设计和方法
通过检索 Pubmed、Embase、ISI、OVID 和 EBSCO 数据库，确定了 15 篇文献。使用比值比及其 95%置信区间来评估 IL-13 多态性与哮喘风险之间的关联。
结果
IL-13 基因中的 R130Q（rs20541）和-1112C/T（rs1800925）多态性与哮喘的总体风险显著增加相关。亚组分析显示，这种升高的风险出现在成年起病的哮喘、白种人和高质量的研究中。
结论
这项荟萃分析提供了证据，表明 IL-13 中的 R130Q 和-1112C/T 多态性是哮喘的危险因素。
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