SIRT6 和 SIRT7 作为头颈部鳞状细胞癌循环标志物的潜力。
The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.
机构信息
Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City, Taiwan, R.O.C.
Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City, Taiwan, R.O.C. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan, R.O.C.
出版信息
Anticancer Res. 2014 Dec;34(12):7137-43.
BACKGROUND
We have previously demonstrated altered SIRT gene family in head and neck squamous cell carcinoma (HNSCC). In the present study we aimed to investigate whether the SIRT gene family was also altered in peripheral blood (PB) of patients with HNSCC and the possibility to be used as circulating biomarkers.
PATIENTS AND METHODS
The expression profiles of the 7 SIRT genes of PB leukocytes from 34 patients with HNSCC before and after surgery and 31 healthy individuals were investigated.
RESULTS
In the cancer group, the expression level of SIRT1 was down-regulated (p<0.05); in contrast, SIRT6 and SIRT7 were significantly up-regulated (p<0.001). Patients with advanced-stage HNSCC had lower expression of SIRT1 and SIRT3. Recovery of SIRT6 and SIRT7 was observed in postoperative patients (p<0.005).
CONCLUSION
SIRT genes were altered in PB leukocytes of HNSCC patients and SIRT6 and SIRT7 are potential circulating prognostic markers for HNSCC.
背景
我们之前已经证明头颈部鳞状细胞癌（HNSCC）中 SIRT 基因家族发生改变。在本研究中，我们旨在研究 SIRT 基因家族是否也在 HNSCC 患者的外周血（PB）中发生改变，并探讨其作为循环生物标志物的可能性。
患者和方法
检测了 34 例 HNSCC 患者手术前后 PB 白细胞中 7 个 SIRT 基因的表达谱，并与 31 名健康个体进行比较。
结果
在癌症组中，SIRT1 的表达水平下调（p<0.05）；相反，SIRT6 和 SIRT7 则显著上调（p<0.001）。晚期 HNSCC 患者的 SIRT1 和 SIRT3 表达水平较低。术后患者 SIRT6 和 SIRT7 的表达水平恢复（p<0.005）。
结论
HNSCC 患者 PB 白细胞中的 SIRT 基因发生改变，SIRT6 和 SIRT7 是 HNSCC 潜在的循环预后标志物。
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