The Chorus Group, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285 USA.
Nat Rev Drug Discov. 2015 Jan;14(1):17-28. doi: 10.1038/nrd4497. Epub 2014 Dec 15.
Chorus is a small, operationally independent clinical development organization within Eli Lilly and Company that specializes in drug development from candidate selection to clinical proof of concept. The mission of Chorus is to achieve proof of concept rapidly and at a low cost while positioning successful projects for 'pharma-quality' late-stage development. Chorus uses a small internal staff of experienced drug developers and a network of external vendors to design and implement chemistry, manufacturing and control processes, preclinical toxicology and biology, and Phase I/II clinical trials. In the decade since it was established, Chorus has demonstrated substantial productivity improvements in both time and cost compared to traditional pharmaceutical research and development. Here, we describe its development philosophy, organizational structure, operational model and results to date.
合唱团是礼来公司内一个小型的、运营独立的临床开发组织，专门从事从候选药物选择到临床概念验证的药物开发。合唱团的使命是在以较低成本实现快速概念验证的同时，为成功项目定位进行“制药质量”的后期开发。合唱团利用内部一支经验丰富的药物开发人员小团队和外部供应商网络来设计和实施化学、制造和控制过程、临床前毒理学和生物学，以及 I/II 期临床试验。自成立以来的十年中，合唱团在时间和成本方面都显著提高了生产力，与传统的制药研发相比。在这里，我们描述了它的发展理念、组织结构、运营模式和迄今为止的成果。
